A while ago I thought, since modern browsers show you PDF documents conveniently in the same window, could you make links work and have a dynamic webside that serves PDF pages?
But yes ofcourse you can. Then I also recalled it's possible for a PDF document to have form fields you can fill in. I tried, but the PDF viewers in modern browsers don't appear to support those. (Yet? Give me a ring if they ever do and I'll see what I can do.)